There are 3 different types of acetylcholinesterase inhibitors – short-acting, medium-duration and irreversible inhibitors, which differ in their interactions with the active site of acetylcholinesterase. Neostigmine is a medium-duration acetylcholinesterase inhibitor that enhances cholinergic transmission in the central nervous system, autonomic nervous system and at neuromuscular junctions. Acetlycholinesterase inhibitors are an established therapy for Alzheimer’s disease and dementia.