CNS Image Bank:
Dementia - Affected areas

The areas of the brain affected in Alzheimer’s disease

The hippocampus is the area of the brain most affected by Alzheimer’s disease. It is there that the characteristic lesions of Alzheimer’s disease — neurofibrillary tangles and neuritic plaques — can be found. Neuritic plaques also occur throughout the neocortex. Atrophy of the parietal and temporal lobes is observed, as seen in the Alzheimer’s diseased brain is associated with disorientation in space and loss of language and memory.