Genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of bipolar disorder. DNA markers (D12S97, D12S342 and D12S1639) have identified regions of interest (12q and 12q22-24) on the long arm of chromosome 12. In some bipolar families, region 12q23-q24.1 has been implicated. This region is found to co-segregate with the ATP2A2 gene. The gene encodes a calcium transporter that is implicated in Darier’s disease, a rare inherited skin condition that commonly co-exists with psychiatric disorders.
Although no single gene has been identified in the inheritance of bipolar disorder, genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of the disorder. A region on the short arm of chromosome 16 (16p) has been identified that may lead to an increased risk of bipolar disorder. The precise genes associated with this region and their functions in the brain have not been identified.
Genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of bipolar disorder. Three DNA markers (PFKL, D21S1260 and D21S263) have identified a region of interest (21q22) on the long arm of chromosome 21. The human homologue of the drosophila white gene at region 21q22.3, which encodes a tryptophan transporter has also shown a significant association with mood disorders.
Although no single gene has been identified in the inheritance of bipolar disorder, genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of the disorder. Two DNA markers (D4S1582 and D4S2949) have identified a region of interest on the short arm of chromosome 4 (4p) that may lead to an increased risk of bipolar disorder. In addition, an association with the DRD5 gene, which encodes the dopamine D5 receptor, has been identified in some bipolar families.
Although no single gene has been identified in the inheritance of bipolar disorder, genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of the disorder. In particular, regions on chromosomes 4 (4p), 12 (12q23-q24.1 and 12q22-24), 16 (16p), 21 (21q22.3 and 21q22) and X (Xq24-27.1 and Xq22.1) have been implicated. The precise genes associated with these regions and their functions in the brain have not been identified.
Genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of bipolar disorder. Two regions of interest, Xq22.1 (DNA marker DXS6789) and Xq24-27.1, have been identified on the long arm of the X chromosome that may lead to an increased risk of bipolar disorder. The precise genes associated with these regions and their functions in the brain have not been identified.