Nicotinic receptor agonist

The nicotinic acetylcholine receptor is one of the main mediators of neurotransmission. This receptor is activated by the binding of two acetylcholine molecules. As a ligand gated ion channel it permits the movement of positively charged ions from the synaptic cleft into the cytoplasm.

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References

How drugs act: molecular aspects. In: Pharmacology, 3rd edition. Rang HP, Dale MM and Ritter JM. Edinburgh, UK: Harcourt Publishers Ltd, 2001:19–46.