Nicotinic-type acetylcholine receptor
The nicotinic acetylcholine receptor is one of the main mediators of neurotransmission. This receptor is activated by the binding of two acetylcholine molecules. It is a ligand gated ion channel, which permits the movement of positively charged ions out of the synaptic cleft. The receptor is composed of five sub-units – two alpha, one beta, one gamma and one delta sub-unit.
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References
How drugs act: molecular aspects. In: Pharmacology, 3rd edition. Rang HP, Dale MM and Ritter JM. Edinburgh, UK: Harcourt Publishers Ltd, 2001:19–46.