5-HT1A receptor antagonist

gA 5-HT1A receptor antagonist prevents the activation of the 5-HT1A receptor. The 5-HT1A receptor is coupled to inhibitory G-proteins, which dissociate from the receptor on agonist binding, and inhibit secondary messenger signaling mechanisms. Antagonist binding inhibits this usual process, resulting in cell depolarisation

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References

How drugs act: molecular aspects. In: Pharmacology, 4^th edition. Rang HP, Dale MM and Ritter JM. Edinburgh, UK: Harcourt Publishers Ltd, 2001:2–46.

Histamine, serotonin, & the ergot alkaloids. In: Basic and clinical pharmacology, 8^th edition. Katzung BG. USA: The McGraw Hill Companies, Inc, 2001:265–291.