NMDA antagonist
The NMDA receptor can be modulated by a number of antagonists, including competitive antagonists at the glycine and glutamate binding sites and non-competitive NMDA receptor channel blockers. Since NMDA receptor activation is dependent on the binding of both glycine and glutamate, the binding of an antagonist at either of these sites prevents activation and opening of the channel.
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References
Amino acid transmitters. In: Pharmacology, 3rd edition. Rang HP, Dale MM and Ritter JM. Edinburgh, UK: Harcourt Publishers Ltd, 2001:470–482.