The molecular genetics of bipolar disorder – chromosome 4
Although no single gene has been identified in the inheritance of bipolar disorder, genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of the disorder. Two DNA markers (D4S1582 and D4S2949) have identified a region of interest on the short arm of chromosome 4 (4p) that may lead to an increased risk of bipolar disorder. In addition, an association with the DRD5 gene, which encodes the dopamine D5 receptor, has been identified in some bipolar families.
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References
Curr Psychiatry Rep 2000;2:147–157.