The molecular genetics of bipolar disorder – chromosome 21
Genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of bipolar disorder. Three DNA markers (PFKL, D21S1260 and D21S263) have identified a region of interest (21q22) on the long arm of chromosome 21. The human homologue of the drosophila white gene at region 21q22.3, which encodes a tryptophan transporter has also shown a significant association with mood disorders.
Click the image to view high resolution version
References
Curr Psychiatry Rep 2000;2:147–157.