The molecular genetics of bipolar disorder – chromosome 12
Genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of bipolar disorder. DNA markers (D12S97, D12S342 and D12S1639) have identified regions of interest (12q and 12q22-24) on the long arm of chromosome 12. In some bipolar families, region 12q23-q24.1 has been implicated. This region is found to co-segregate with the ATP2A2 gene. The gene encodes a calcium transporter that is implicated in Darier’s disease, a rare inherited skin condition that commonly co-exists with psychiatric disorders.
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References
Curr Psychiatry Rep 2000;2:147–157.
Br J Psychiatry Suppl 2001;41:s128–133.