The areas of the brain affected in Alzheimer’s disease
The hippocampus is the area of the brain most affected by Alzheimer’s disease. It is there that the characteristic lesions of Alzheimer’s disease — neurofibrillary tangles and neuritic plaques — can be found. Neuritic plaques also occur throughout the neocortex. Atrophy of the parietal and temporal lobes is observed, as seen in the Alzheimer’s diseased brain is associated with disorientation in space and loss of language and memory.
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References
Corpus striatum. In: Neuroanatomy, an illustrated colour text. Crossman AR and Neary D. New York, USA: Churchhill Livingstone, 1995:119–127.
Cerebral hemisphere and cerebral cortex. In: Neuroanatomy, an illustrated colour text. Crossman AR and Neary D. New York, USA: Churchill Livingstone, 1995:101–117.
Alzheimer’s disease and stroke: possible biochemical causes and treatment strategies. In: Fundamentals of Psychopharmacology, 2nd edition. Leonard BE. Chichester, England: John Wiley and Sons, 1992:249–273.