Changes in gene expression following administration of antidepressants: serotonin transporter

Tricyclic antidepressants and selective serotonin re-uptake inhibitors rapidly bind to and block the action of serotonin re-uptake transporters (SERTs). Chronic administration of these types of antidepressants leads to changes in SERT gene expression. A significant increase in SERT expression is seen in the hippocampus and the cingulate, insular, perirhinal and parietal cortices in response to chronic antidepressant treatment.

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