Distribution of 5-HT5 receptors in the brain
To date seven main types of 5-HT receptor have been identified in the brain. Two 5-HT5 receptor subtypes (5-HT5A, 5-HT5B) have also been recognised. The main sites of 5-HT5A mRNA expression are the cerebral cortex, hippocampus, hypothalamic area, amygdala and cerebellum. However, the physiological role of this receptor in normal brain function is still unknown. The human 5-HT5B gene does not encode a functional protein because its coding sequence is interrupted by stop codons.
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