Distribution of 5-HT2 receptors in the brain of those affected by depression

In depression the distribution of 5-HT2 receptors is altered compared with the normal brain. The 5-HT2 receptor density is decreased in the frontal, temporal, parietal and occipital cortical regions compared with normal. 5-HT2 expression in the hippocampus, basal ganglia, substantia nigra, hypothalamus, choroid plexus and substantia innominata remains unaffected by depression.

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References

Arch Gen Psychiatry 2000;57:850–858.

Nuklearmedizin 2002;40:129–134