The serotonin pathways in depression

Serotonin transmission from both the caudal raphe nuclei and rostal raphe nuclei is reduced in patients with depression compared with non-depressed controls. Increasing the levels of serotonin in these pathways, by reducing serotonin reuptake and hence increasing serotonin function, is one of the therapeutic approaches to treating depression.

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References

Neural plasticity and disorders of the nervous system. In: Neuroscience at a glance, Barker RA and Barasi S with Neal MJ. London, England, 1999:105–121.