The serotonin pathways in Alzheimer’s disease

The principal serotonin centres in the brain are the caudal and rostral raphe nuclei. Transmission of serotonin descending from the rostral raphe nuclei to the temporal lobe is decreased in Alzheimer’s disease compared with normal. The other major pathways for serotonin transmission, which project to the cerebellum and frontal lobe and descend the spinal cord, remain unchanged.

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References

Neurotransmitters and psychiatric disorders. In: Psychiatric disorders with a biochemical basis. Donaldson D. Carnthorn, UK: The Parthenon Publishing Group Inc, 1998: 45–55.