The noradrenaline pathways in mania

The principal noradrenaline centres in the brain are the caudal nuclei and the locus coeruleus. The transmission of noradrenaline from both of these centres to all areas of the brain is thought to be increased in mania compared with a non-diseased brain.

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References

Neurotransmitters and psychiatric disorders. In: Psychiatric disorders with a biochemical basis. Donaldson D. Carnthorn, UK: The Parthenon Publishing Group Inc, 1998: 45–55.