The noradrenaline pathways in depression

In depression the transmission of noradrenaline is reduced from both of the principal noradrenergic centres – the locus coeruleus and the caudal raphe nuclei. An increase in noradrenaline in the frontal/prefrontal cortex modulates the action of selective noradrenaline reuptake inhibition and improves mood. Increasing noradrenaline transmission to other areas of the frontal cortex modulates attention.

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References

Neurotransmitters and psychiatric disorders. In: Psychiatric disorders with a biochemical basis. Donaldson D. Carnthorn, UK: The Parthenon Publishing Group Inc, 1998: 45–55.