The noradrenaline pathways in the brain

Many regions of the brain are supplied by the noradrenergic systems. The principal centres for noradrenergic neurones are the locus coeruleus and the caudal raphe nuclei. The ascending nerves of the locus coeruleus project to the frontal cortex, thalamus, hypothalamus and limbic system. Noradrenaline is also transmitted from the locus coeruleus to the cerebellum. Nerves projecting from the caudal raphe nuclei ascend to the amygdala and descend to the midbrain.

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References

Drugs in health and disease. In: Integrated Pharmacology. Page, Curtis, Sutter et al. London, UK: Mosby International, 1997: 92–151.