The glutamate pathways in the ‘normal’ brain

In the normal brain the prominent glutamatergic pathways are: the cortico-cortical pathways; the pathways between the thalamus and the cortex; and the extrapyramidal pathway (the projections between the cortex and striatum). Other glutamate projections exist between the cortex, substantia nigra, subthalmic nucleus and pallidum. Glutamate-containing neuronal terminals are ubiquitous in the central nervous system and their importance in mental activity and neurotransmission is considerable.

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References

Int Clin Psychopharmacol 1995;10(Suppl 3):21–28.

Brain structures and neuronal projections. Institute of Chemistry, Pharmacology and Biomedical Sciences. University of Sunderland. http://abdellab.sunderland.ac.uk/lectures/Brain/glu1.html. Accessed on 21 March 2003.