Changes in gene expression following administration of antidepressants: noradrenaline transporter

Tricyclic antidepressants and selective noradrenaline re-uptake inhibitors rapidly bind to and block the action of noradrenaline re-uptake transporters (NARTs). Chronic administration of these antidepressants leads to changes in NART gene expression. A significant increase in NART expression is seen in the hippocampus and the in cingulate, frontal, parietal, perirhinal, entorhinal and insular cortices in response to chronic antidepressant treatment. A decrease in NART expression is seen in the temporal cortex.

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