The molecular genetics of bipolar disorder
Although no single gene has been identified in the inheritance of bipolar disorder, genetic linkage studies have indicated distinct regions on several chromosomes that may be associated with a family history of the disorder. In particular, regions on chromosomes 4 (4p), 12 (12q23-q24.1 and 12q22-24), 16 (16p), 21 (21q22.3 and 21q22) and X (Xq24-27.1 and Xq22.1) have been implicated. The precise genes associated with these regions and their functions in the brain have not been identified.
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References
Curr Psychiatry Rep 2000;2:147–157.
Br J Psychiatry Suppl 2001;41:s128–133.