The mechanism of action of nefazodone (efficacy)
The antidepressant nefazodone is thought to alleviate some of the symptoms of depression by enhancing 5-HT neurotransmission. Ii inhibits the re-uptake of 5-HT and acts as an antagonist at 5-HT2 receptors. These two mechanisms may enhance 5-HT1A mediated neurotransmission. Nefazodone also weakly inhibits the re-uptake of noradrenaline. Two of the three metabolites of nefazodone (hydroxynefazodone and m-chlorophenylpiperazine) have similar affinities to the parent compound.
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References
Am J Health Syst Pharm 1995;52:2799–2812.
Nefazodone (Serzone®). Massachusetts and Rhode Island Poison Centre. http://www.maripoisoncenter.com/ctr/9807nefazodone.html. Accessed on 24 March 2003.