The mechanism of action of nefazodone (adverse effects)

The antidepressant nefazodone is thought to alleviate some of the symptoms of depression by inhibiting the re-uptake of 5-HT and acting as an antagonist at 5-HT2 receptors. Antagonism of noradrenaline α1 receptors leads to some of the adverse effects associated with nefazodone treatment, such as postural hypotension.

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