The adenosine receptor (A1/A3 receptor)

There are at least four subtypes of the adenosine receptor ¾ A1, A2A, A2B and A3 receptors. Adenosine receptors are all coupled to G-proteins and the A1 and A3 subtypes are associated with inhibitory G-proteins. Activation of the A1 and A3 receptors causes inhibition of adenylate cyclase and phospholipase C, which inhibits neurotransmission. The A1 receptors are highly expressed in the brain, especially in the hippocampus, thalamus, cerebellum and cortex. The A3 receptors are moderately expressed in the brain

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References

Adenosine receptor A. Affinity bioreagents. http://www.bioreagents.com/index.cfm/fuseaction/products.detail/Product/PA1-041 Accessed on 7 May 2002.

The pharmacology and biochemistry of adenosine receptors. The University of Nottingham. http://www.nottingham.ac.uk/~mqzwww/adenosine.html Accessed on 7 May 2002.

Pharmacol Rev. 1998 Sep;50(3):413-492.