Distribution of 5-HT6 and 5-HT7 receptors in the brain
The 5-HT6 and 5-HT7 subtypes of serotonin receptor are coupled to a G-protein that stimulates the intracellular messenger adenylate cyclase that, in turn, regulates neurotransmission. In the human brain, a high density of -5HT6 receptors has been identified in the olfactory tubercle, corpus striatum, nucleus accumbens, dentate gyrus and hippocampus. Lower levels of expression of the 5-HT6 receptor have been shown in the cerebellum and amygdala. Studies in the rat suggest the 5-HT7 receptor is widely distributed in the brain; examination of human brain tissue has shown expression in the thalamus.
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References
Ann NY Acad Sci 1998;861:91–96.
Neuropharmacology 2002;42:74–81.