Distribution of 5-HT4 receptors in the brain
The 5-HT4 receptor subtype is coupled to a G-protein that stimulates the intracellular messenger adenylate cyclase that, in turn, regulates neurotransmission. In the human brain, a high density of 5-HT4 receptors has been identified in the striato-nigral system, notably in the caudate nucleus, lenticular nucleus (putamen and globus pallidus) and the substantia nigra. Lower levels of expression of the 5-HT4 receptor have been shown in the hippocampus and the frontal cortex.
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References
Neuroreport 1993;4:1239–1242.
Br J Pharmaco 1995;114:993–998.