The 5-HT3 receptor
The 5-HT3 receptor is distinct from the other 5-HT receptor subtypes, in that it is a ligand-gated ion channel that is permeable to sodium and potassium. The 5-HT3 receptor is structurally similar to the nicotinic acetylcholine receptor and is composed of 5 subunits. Two subunits have been cloned, 5-HT3A and 5-HT3B, and homomeric (5-HT3A) and heteromeric (5-HT3A/5-HT3B) forms of the receptor have both been characterised
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References
Histamine, serotonin and the ergot alkaloids. In: Basic and clinical pharmacology, 8th edition. Katzung BG. USA: The McGraw Hill Companies, Inc, 2001:265–291.
Dr Tony Hope, Department of Pharmacology, Division of Neuroscience. University of Birmingham. http://medweb.bham.ac.uk/http/depts/pharm/staffresearch/hope.htm Accessed on 24 April 2002.