Distribution of 5-HT3 receptors in the brain
The 5-HT3 receptor subtype is a ligand-gated ion channel that controls dopamine release. It is a common target of antiemetic therapy, as well as other psychoactive drugs. A high density of 5-HT3 receptors has been identified in the human brainstem, particularly in the area postrema (the putative vomiting center of the brain) and the nucleus tractus solitarius. Lower levels of expression of the 5-HT3 receptor have been shown in the limbic system, hippocampus and the cerebral cortex.
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References
Neurosci Lett 1990;111:80–86.
Neurochem Res 2001;26:187–190.